Methotrexate Levels After 24 Hours

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A Family Physician's Guide to Monitoring Methotrexate

    https://www.aafp.org/pubs/afp/issues/2000/1001/p1607.html
    Methotrexate is administered once weekly as a single dose or in divided doses given over a 24-hour period. To reduce the incidence of major toxic effects, methotrexate should never be given...

Delayed methotrexate clearance - Oncology Nurse Advisor

    https://www.oncologynurseadvisor.com/home/departments/ask-a-pharmacist/delayed-methotrexate-clearance/
    High-dose methotrexate is administered for certain types of cancer, and generally includes doses of 500 mg/m 2 or higher. These regimens deliver high doses of …

Therapeutic use and toxicity of high-dose methotrexate

    https://www.uptodate.com/contents/therapeutic-use-and-toxicity-of-high-dose-methotrexate
    Management of patients with renal failure and prolonged high plasma methotrexate levels - Augmenting urine output - Increased dose and frequency of …

Methotrexate Level - Laboratory Test Directory

    https://spectrumhealth.testcatalog.org/show/LAB481-1
    Criteria for serum concentrations indicative of a potential for toxicity after single-bolus, high-dose therapy are as follows:-Methotrexate >10 mcmol/L 24 hours after dose …

Methotrexate - GlobalRPH

    https://globalrph.com/oncology/methotrexate/
    Serum methotrexate level approximately 10 micromolar at 24 hours after administration, 1 micromolar at 48 hours, and less than 0.2 micromolar at 72 hours. 15 …

Methotrexate - StatPearls - NCBI Bookshelf

    https://www.ncbi.nlm.nih.gov/books/NBK556114/
    A single dose of glucarpidase reduces plasma methotrexate concentrations by 97% or more within 15 minutes. Hydration and urine alkalinization is …

Methotrexate levels, a guide to therapy? - PubMed

    https://pubmed.ncbi.nlm.nih.gov/6681135/
    From a study of the serum levels of this drug, we believe that 10 mg intramuscularly once per week should be an optimum method of treating arthritis. The measurement of a 24 …

Monitoring Methotrexate Levels in a Patient …

    https://www.jhoponline.com/jhop-issue-archive/2020-issues/june-2020-vol-10-no-3/18224-monitoring-methotrexate-levels-in-a-patient-after-glucarpidase-administration-a-case-report
    Methotrexate levels should be monitored at predefined time points; if a level exceeds the nomogram threshold for a certain time, the patient is at risk for delayed clearance …

Preventing and Managing Toxicities of High …

    https://theoncologist.onlinelibrary.wiley.com/doi/10.1634/theoncologist.2015-0164
    High-dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m2, is used to treat a range of adult and childhood cancers. Although HDMTX is safely …

Methotrexate Side Effects: Common, …

    https://www.drugs.com/sfx/methotrexate-side-effects.html
    Very common (10% or more): Anorexia, nausea, vomiting, abdominal pain, inflammation, ulcerations of the mucous membrane of mouth and throat (especially …

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